From Tim Keller’s sermon, “Promise of Hope”:

God designed life, i.e. what we think of as our relationship to God (spiritual), to ourselves (psychological), to others (social), and to nature. When we sin, God doesn’t “punish” us by heaping curses on us, but by allowing us to live as our own masters, that is, in ways that contravenes God’s designs. We experience frustration because our souls long for something better, but we can’t get at it unless we acknowledge that God is God.

The consequence of sin is alienation in all the realms of our lives: spiritual, self/psychological, social, and from nature.

Living in sin means living with the frustrations of wanting a perfect life, but not being able to get it. 

The remedy?

Genesis 3:14-15

Even as God pronounced--pronounced as a statement of fact--curses as the result of sin, he couldn’t help himself but to also announce even then the coming of redemption. He couldn't wait because he is the God who can’t wait to bless even when to bless means the greatest sacrifice.